Debating obesity the disease
Source: MedScape
Follow the Money?
Fat Equals Sick: Is This About the Money?
Getting Paid for Treating Obesity, Now That It's a Disease
AMA: Diagnosis by Majority
Is It an Addiction? Can Obesity Be an Addiction?
Also Weighing in on the Disease Debate Obesity: It's a Risk! It's a Symptom! It's a Disease!
Obesity as a Disease? 'It's Academic'
News Behind the Perspectives AMA Declares Obesity a Disease
Obesity Disease Classification Will Help With Treatment, Docs Say
Showing posts with label Obesity. Show all posts
Showing posts with label Obesity. Show all posts
Saturday, July 20, 2013
Thursday, June 27, 2013
American Medical Association declared obesity a “disease.”
American Medical Association declared obesity a “disease.”
"RESOLVED, That our American Medical Association recognize obesity as a disease state with 24 multiple pathophysiological aspects requiring a range of interventions to advance obesity 25 treatment and prevention. (New HOD Policy - Resolution 420)" - 06/16/2013
"RESOLVED, That our American Medical Association recognize obesity as a disease state with 24 multiple pathophysiological aspects requiring a range of interventions to advance obesity 25 treatment and prevention. (New HOD Policy - Resolution 420)" - 06/16/2013
- New York Times (2013). A.M.A. Recognizes Obesity as a Disease
- Time.com (2013). The Best Cure for Obesity? Personal Responsibility.
- Boston.com (2013). Has obesity been mislabeled as a disease? Why doctors don’t mind.
- Bays (2013). Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association.
Saturday, May 11, 2013
Does 3 minutes of exercise and two fasts a week (5:2) work?
Does 3 minutes of exercise and two fasts a week (5:2) and others
A few weeks ago, I watched a presention on PBS channel by Dr. Michael Mosley about he dealed with his high blood glucose (diabetes). He amazingly found 3 minutes of exercise and two fasts a week works for him.
Francesco (2018): A time to fast, Ludwig (2018): Dietary fat: From foe to friend?
A few weeks ago, I watched a presention on PBS channel by Dr. Michael Mosley about he dealed with his high blood glucose (diabetes). He amazingly found 3 minutes of exercise and two fasts a week works for him.
- This new diet mimics fasting by “rebooting” the body - State Column (2015)
- Reaping The Health Benefits Of Fasting Without Actually Fasting - Forbes (2015)
- Brandhorst (2015). A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan
- 'FastDiet' book is attracting dieters, and doubters - USA Today
- 'The Fast Diet': Recipes for Low-Calorie Meals - ABCNews
- Michael Mosley: 'The Fast Diet' Author On Self-Experimentation, Fasting And Coming To America - Huffington Post
- 3 Minutes of Exercise and Two Fasts a Week: Is This the Future of Fitness?
- Feast and Famine: Controversial 'Fast Diet' Weight Loss Plan Is Eat for 5 Days, Fast for 2 - ABCNews
- The fast diet - Michael Mosley
Francesco (2018): A time to fast, Ludwig (2018): Dietary fat: From foe to friend?
- Howard (2017). Does fasting on alternate days work? A new study weighs in
Friday, March 29, 2013
Fructose or not Fructose
Fructose or not Fructose
- Fructose: It’s "Alcohol Without the Buzz" - Robert H. Lustig
- Sucrose, High-Fructose Corn Syrup, and Fructose, Their Metabolism and Potential Health Effects: What Do We Really Know? - James M. Rippe and Theodore J. Angelopoulos
- What Do Government Agencies Consider in the Debate Over Added Sugars? - David M. Klurfeld
Tuesday, February 12, 2013
Thin Asians at Risk for Diabetes Due to Hidden Body Fat
Thin Asians at risk for diabetes due to hidden body fat
Source: MedScape.come by Lisa Nainggolan
Type 2 diabetes, usually associated with obesity, can occur in many seemingly thin people from ethnic minorities, physicians told attendees here at the Excellence in Diabetes 2013 meeting last week.
Researchers showed that Japanese American women are twice as likely to be diagnosed with diabetes as whites, despite having lower body-mass indexes (BMIs). Epidemiologist Gertraud Maskarinec, MD, from the University of Hawaii Cancer Center, Honolulu, presented the findings, which cover a number of studies from her group, in a poster.
She told Medscape Medical News: "Diabetes risk is higher in all ethnic groups than in whites, and of course some of this is just due to body weight, but evidence is now building that people of many races may be at increased risk of diabetes and cancer before they are even considered conventionally overweight."
In communities where there are a lot of Asians, "I think it's on everybody's radar already," said Dr. Maskarinec. "If an Asian walks in, you don’t have to wait until they weigh hundreds of pounds to do a diabetes test." The World Health Organization (WHO) has worked on the idea to lower the "at-risk" BMI to 23 kg/m2 for certain ethnic groups, she adds, but "not everybody has adopted it."
Meanwhile, Chittaranjan Yajnick, MD, from King Edward Memorial Diabetes Unit, Pune, India, also gave a talk on what makes Indians so susceptible to diabetes. "We have seen that Indians are often diagnosed with diabetes 10 years earlier and 5- to 10-units BMI thinner than whites," he noted.
Both believe the explanation lies in "hidden" visceral fat found inside the body, between organs, in Asians and probably other ethnic groups too, but not in whites. This in turn affects the levels of adipokines secreted, such as leptin and adiponectin, which can have adverse metabolic effects. ...full text ...
Source: MedScape.come by Lisa Nainggolan
Type 2 diabetes, usually associated with obesity, can occur in many seemingly thin people from ethnic minorities, physicians told attendees here at the Excellence in Diabetes 2013 meeting last week.
Researchers showed that Japanese American women are twice as likely to be diagnosed with diabetes as whites, despite having lower body-mass indexes (BMIs). Epidemiologist Gertraud Maskarinec, MD, from the University of Hawaii Cancer Center, Honolulu, presented the findings, which cover a number of studies from her group, in a poster.
She told Medscape Medical News: "Diabetes risk is higher in all ethnic groups than in whites, and of course some of this is just due to body weight, but evidence is now building that people of many races may be at increased risk of diabetes and cancer before they are even considered conventionally overweight."
In communities where there are a lot of Asians, "I think it's on everybody's radar already," said Dr. Maskarinec. "If an Asian walks in, you don’t have to wait until they weigh hundreds of pounds to do a diabetes test." The World Health Organization (WHO) has worked on the idea to lower the "at-risk" BMI to 23 kg/m2 for certain ethnic groups, she adds, but "not everybody has adopted it."
Meanwhile, Chittaranjan Yajnick, MD, from King Edward Memorial Diabetes Unit, Pune, India, also gave a talk on what makes Indians so susceptible to diabetes. "We have seen that Indians are often diagnosed with diabetes 10 years earlier and 5- to 10-units BMI thinner than whites," he noted.
Both believe the explanation lies in "hidden" visceral fat found inside the body, between organs, in Asians and probably other ethnic groups too, but not in whites. This in turn affects the levels of adipokines secreted, such as leptin and adiponectin, which can have adverse metabolic effects. ...full text ...
Wednesday, February 06, 2013
Obesity paradox
Obesity paradox
Today Medscape released a special report about 'Obesity Paradox':
Expert Commentary
License to Eat? Obesity and Lower Mortality
The Obesity Paradox: Does It Matter?
Obesity Bests Thinness in Hypertension? Check the Meds
The Obesity Paradox: Does It Matter?
Obesity Bests Thinness in Hypertension? Check the Meds
The Current State of Obesity
Studies on the Obesity Paradox
Tuesday, September 18, 2012
In ‘Obesity Paradox,’ Thinner May Mean Sicker
Source: New York Times
"… Dr. Neil Ruderman, an endocrinologist at Boston University School of Medicine, was the first to identify a condition he called "metabolically obese normal weight," in 1981. Such people have weights in the normal range on the B.M.I. chart but also have metabolic abnormalities, including high levels of insulin resistance and triglycerides; they tend to carry fat around the middle, which is more apt to affect the heart, liver and other organs than fat in the hips and thighs…."
This evidence is not new. I post here to reminder myself about this called 'paradox' (not a paradox to me).
This evidence is not new. I post here to reminder myself about this called 'paradox' (not a paradox to me).
Tuesday, September 11, 2012
Geriatric Obesity - a Special Issue of International Journal of Obesity
International Journal of Obesity just released a special issue on geriatiric obesity. It concluded that more research is needed to clarify the definition, to evaluate the tiem of treatment, and strategies treatment of obesity in older adults.
Scoping review report: obesity in older adults
Scoping review report: obesity in older adults
Obesity in the elderly: an emerging health issue
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Tuesday, August 28, 2012
Fifty Shades of Brown
Fifty Shades of Brown: The Evolving View of Fat
Source: Circulation
This is an editorial article of a PVAT (Perivascular adipose tissue) study supports fat is friend not foe. I have learned decades ago in my medical school that the BAT (brown adipose tissue) which is major thermogenetic fat for an infant, especially cold area of world without heat. Now, researchers find that adults also have the BAT a little bit here and a little bit there.
"...
The relationship between increased body mass index and risk for diabetes mellitus or cardiovascular disease is well established. Such observations have driven considerable interest into the nature of adipose tissue and what mechanisms might help explain how adipose tissue and specific aspects of adipocyte biology influence cardiometabolic disorders. For example, adipocytes are now recognized as a source of mediators released into the circulation, like the adipokines resistin and adiponectin, which can modulate inflammation, insulin sensitivity, and atherosclerosis. Other molecules released from adipocytes like free fatty acids and reactive oxygen species can also exert both local and distant effects that may be integral to the development of diabetes mellitus, atherosclerosis, and their complications. To an increasing extent, adipose tissue is now understood as an organ playing important physiological and pathological roles. Both the absence of fat, as with certain lipodystrophies, and excess adiposity are associated with diabetes mellitus, with mechanisms that appear to include infiltration of inflammatory cells into adipose tissue and the release of systemic mediators.
..."
Source: Circulation
This is an editorial article of a PVAT (Perivascular adipose tissue) study supports fat is friend not foe. I have learned decades ago in my medical school that the BAT (brown adipose tissue) which is major thermogenetic fat for an infant, especially cold area of world without heat. Now, researchers find that adults also have the BAT a little bit here and a little bit there.
"...
The relationship between increased body mass index and risk for diabetes mellitus or cardiovascular disease is well established. Such observations have driven considerable interest into the nature of adipose tissue and what mechanisms might help explain how adipose tissue and specific aspects of adipocyte biology influence cardiometabolic disorders. For example, adipocytes are now recognized as a source of mediators released into the circulation, like the adipokines resistin and adiponectin, which can modulate inflammation, insulin sensitivity, and atherosclerosis. Other molecules released from adipocytes like free fatty acids and reactive oxygen species can also exert both local and distant effects that may be integral to the development of diabetes mellitus, atherosclerosis, and their complications. To an increasing extent, adipose tissue is now understood as an organ playing important physiological and pathological roles. Both the absence of fat, as with certain lipodystrophies, and excess adiposity are associated with diabetes mellitus, with mechanisms that appear to include infiltration of inflammatory cells into adipose tissue and the release of systemic mediators.
..."
Monday, August 06, 2012
Thursday, July 12, 2012
Special issue on lipotoxicity
Editors: A. Vidal-Puig & R.Unger
“It was sometime in March 2009 when our colleague Fritz Spener first proposed a special issue of BBA Molecular and Cell Biology of Lipids focused on the concept of lipotoxicity and its relevance as an integrative pathogenic mechanism of the metabolic syndrome. Although we might have hesitated a little initially, this did not last long as we realised that: a) ours would be a unique, high quality publication addressing the topic in depth and globally; b) this is an important area of research with enormous implications for metabolic disease and, in our opinion, its relevance is underestimated and relatively unknown among both the biomedical community and general public; and c) the great opportunities offered by new technologies and experimental models to understand the role of lipotoxicity in common metabolic diseases makes this a very timely issue. And also, of course, we expected strong support from the “lipotoxic community”. Certainly we have not been disappointed. In fact our colleagues have provided enormous support and their generosity has made this issue viable. Our only regret is that we have not been able to involve as many of the key experts as we wanted due to space constrains and the time scale of the project, and we hope this will not be the cause of any lost friendships!”
Here is the special issue: Special issue on lipotoxicity.
Here is the special issue: Special issue on lipotoxicity.
This issue isn’t new. I have got the similar hypothesis after I attended a lecture by J. Denis McGarry in 2001 (In memory of Dr. John Denis McGarry. His article "What if Minkowski Had Been Ageusic?" is on the wall of my office all the time). I put this special issue on my blog to remind me keeping work on this hypothesis.
Tuesday, July 10, 2012
In Dieting, Magic Isn’t a Substitute for Science
By GINA KOLATA
"Is a calorie really just a calorie? Do calories from a soda have the same effect on your waistline as an equivalent number from an apple or a piece of chicken?"
Thursday, July 05, 2012
Studies of Human Microbiome Yield New Insights
Studies of Human Microbiome Yield New Insights
Source: NYTimes.com by Carl Zimmer
"For a century, doctors have waged war against bacteria, using antibiotics as their weapons. But that relationship is changing as scientists become more familiar with the 100 trillion microbes that call us home - collectively known as the microbiome.
...". Read full article here.
There is also a story about Zhao Liping combines traditional Chinese medicine and studies of gut microbes to understand and fight obesity on the Nature: My Microbiome and Me.
Source: NYTimes.com by Carl Zimmer
"For a century, doctors have waged war against bacteria, using antibiotics as their weapons. But that relationship is changing as scientists become more familiar with the 100 trillion microbes that call us home - collectively known as the microbiome.
...". Read full article here.
There is also a story about Zhao Liping combines traditional Chinese medicine and studies of gut microbes to understand and fight obesity on the Nature: My Microbiome and Me.
Tuesday, May 08, 2012
Metabolic surgery for type 2 diabetes and obesity related - Nature Medicine
Metabolic surgery for type 2 diabetes
David E Cummings
Clinicians note that bariatric operations can dramatically resolve type 2 diabetes, often before and out of proportion to postoperative weight loss. Now two randomized controlled trials formally show superior results from surgical compared with medical diabetes care, including among only mildly obese patients. The concept of 'metabolic surgery' to treat diabetes has taken a big step forward.
Topic: Guts over glory - why diets fail
Rachel Larder and Stephen O'Rahilly
Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real struggle. A major health problem for obese people is that diseases linked to obesity, such as type 2 diabetes and cardiovascular disease, put their lives at risk, even in young individuals. Although bariatric surgery[mdash]a surgical method to reduce or modify the gastrointestinal tract[mdash]was originally envisioned for the most severe cases of obesity, evidence suggests that the benefit of this procedure may not be limited to the staggering weight loss it causes. Endogenous factors released from the gut, and modified after surgery, may explain why bariatric surgery can be beneficial for obesity-related diseases and why operated individuals successfully maintain the weight loss. In 'Bedside to Bench,' Rachel Larder and Stephen O'Rahilly peruse a human study with dieters who regained weight despite a successful diet. Appetite-regulating hormones in the gut may be responsible for this relapse in the long term. In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham examine how two different methods of bariatric surgery highlight the relevance of gut-derived hormones not only in inducing sustained weight loss but also in improving glucose homeostasis. These insights may open new avenues to bypass the surgery and obtain the same results with targeted drugs.
Topic: Metabolic insights from cutting the gut
Keval Chandarana and Rachel L Batterham
Losing weight can pose a challenge, but how to avoid putting those pounds back on can be a real truggle. A major health problem for obese people is that diseases linked to obesity, such as type 2 diabetes and cardiovascular disease, put their lives at risk, even in young individuals. Although bariatric surgery[mdash]a surgical method to reduce or modify the gastrointestinal tract[mdash]was originally envisioned for the most severe cases of obesity, evidence suggests that the benefit of this procedure may not be limited to the staggering weight loss it causes. Endogenous factors released from the gut, and modified after surgery, may explain why bariatric surgery can be beneficial for obesity-related diseases and why operated individuals successfully maintain the weight loss. In 'Bedside to Bench,' Rachel Larder and Stephen O'Rahilly peruse a human study with dieters who regained weight despite a successful diet. Appetite-regulating hormones in the gut may be responsible for this relapse in the long term. In 'Bench to Bedside,' Keval Chandarana and Rachel Batterham examine how two different methods of bariatric surgery highlight the relevance of gut-derived hormones not only in inducing sustained weight loss but also in improving glucose homeostasis. These insights may open new avenues to bypass the surgery and obtain the same results with targeted drugs.
Friday, January 06, 2012
Unraveling the Obesity-Cancer Connection
Unraveling the Obesity-Cancer Connection
By Gary Taubes
Summary
Insulin, a hormone produced in the pancreas, is more commonly known for its role in diabetes. But its reputation may be changing. Insulin and a related hormone known as insulin-like growth factor (IGF) are now at the center of a growing wave of research around the world aimed at elucidating what many scientists consider to be their critical role in fueling a wide range of cancers. Elevated levels of insulin and IGF are also the leading candidates to explain a significant correlation in epidemiology that has gained attention over the past 30 years: Obese and diabetic individuals have a far higher risk than lean healthy people of getting cancer, and when they do get it, their risk of dying from it is greater. And now that obesity and diabetes rates are skyrocketing, the need to understand this link has become far more urgent. ...
Read the full text here
By Gary Taubes
Summary
Insulin, a hormone produced in the pancreas, is more commonly known for its role in diabetes. But its reputation may be changing. Insulin and a related hormone known as insulin-like growth factor (IGF) are now at the center of a growing wave of research around the world aimed at elucidating what many scientists consider to be their critical role in fueling a wide range of cancers. Elevated levels of insulin and IGF are also the leading candidates to explain a significant correlation in epidemiology that has gained attention over the past 30 years: Obese and diabetic individuals have a far higher risk than lean healthy people of getting cancer, and when they do get it, their risk of dying from it is greater. And now that obesity and diabetes rates are skyrocketing, the need to understand this link has become far more urgent. ...
Read the full text here
Wednesday, January 04, 2012
New Ways Calories Can Add Up to Weight Gain
Source: WSJ.com
"Whether you are just starting a New Year's diet or struggling to maintain a healthy weight, a provocative new study offers some timely guidance. It isn't so much what you eat, the study suggests, but how much you eat that counts when it comes to accumulating body fat.
The findings are the latest in a string of studies to challenge claims that the secret to healthy weight loss lies in adjusting the amount of nutritional components of a diet—protein, fat and carbohydrates.
The diet industry has offered dozens of strategies recommending raising or lowering carbohydrates, protein or fat." ...
The original JAMA article and two related articles:
- Bray (2012) Effect of Dietary Protein Content on Weight Gain, Energy Expenditure, and Body Composition During Overeating
- Livingston (2012) Inadequacy of BMI as an Indicator for Bariatric Surgery
- Sjöström (2012) Bariatric Surgery and Long-term Cardiovascular Events
Thursday, December 29, 2011
The Fat Trap - NYTimes.com
The Fat Trap
Source: NYTimes.com
For 15 years, Joseph Proietto has been helping people lose weight. When these obese patients arrive at his weight-loss clinic in Australia, they are determined to slim down. And most of the time, he says, they do just that, sticking to the clinic's program and dropping excess pounds. But then, almost without exception, the weight begins to creep back. In a matter of months or years, the entire effort has come undone, and the patient is fat again. "It has always seemed strange to me," says Proietto, who is a physician at the University of Melbourne. "These are people who are very motivated to lose weight, who achieve weight loss most of the time without too much trouble and yet, inevitably, gradually, they regain the weight." ...
Full text: here
Source: NYTimes.com
For 15 years, Joseph Proietto has been helping people lose weight. When these obese patients arrive at his weight-loss clinic in Australia, they are determined to slim down. And most of the time, he says, they do just that, sticking to the clinic's program and dropping excess pounds. But then, almost without exception, the weight begins to creep back. In a matter of months or years, the entire effort has come undone, and the patient is fat again. "It has always seemed strange to me," says Proietto, who is a physician at the University of Melbourne. "These are people who are very motivated to lose weight, who achieve weight loss most of the time without too much trouble and yet, inevitably, gradually, they regain the weight." ...
Full text: here
Wednesday, December 28, 2011
Obesity
Obesity
Source: TheLancet.com Published August 26, 2011
"This four-part Series critically examines what we know about the global obesity pandemic: its drivers, its economic and health burden, the physiology behind weight control and maintenance, and what science tells us about the kind of actions that are needed to change our obesogenic environment and reverse the current tsunami of risk factors for chronic diseases in future generations."
"The first paper looks at the global drivers of the epidemic; the second paper analyses obesity trends in the USA and UK, and their impact on prevalence of diseases and healthcare spending. The third paper introduces a new web-based bodyweight simulation model, that incorporates metabolic adaptations that occur with decreasing bodyweight; and the final paper assesses the interventions needed to halt and reverse the epidemic. Its authors conclude that the changes needed are likely to require many sustained interventions at several levels, but that national governments should take the lead. "
Full Text: Here
Source: TheLancet.com Published August 26, 2011
"This four-part Series critically examines what we know about the global obesity pandemic: its drivers, its economic and health burden, the physiology behind weight control and maintenance, and what science tells us about the kind of actions that are needed to change our obesogenic environment and reverse the current tsunami of risk factors for chronic diseases in future generations."
"The first paper looks at the global drivers of the epidemic; the second paper analyses obesity trends in the USA and UK, and their impact on prevalence of diseases and healthcare spending. The third paper introduces a new web-based bodyweight simulation model, that incorporates metabolic adaptations that occur with decreasing bodyweight; and the final paper assesses the interventions needed to halt and reverse the epidemic. Its authors conclude that the changes needed are likely to require many sustained interventions at several levels, but that national governments should take the lead. "
Full Text: Here
Thursday, September 15, 2011
Bariatric Surgery and Obesity and Diabetes – International Journal of Obesity, 09/2011
Wednesday, August 10, 2011
Harnessing Systems Science Methodologies To Inform Public Policy: System Dynamics Modeling For Obesity Policy In The Envision Network Friday, July 15, 2011
Chaired by Patricia L. Mabry, Ph.D., Office of Behavioral and Social Sciences Research, NIH. Speakers: Hazhir Rahmandad, Ph.D, Virginia Tech; Peter Hovmand, Ph.D., Washington University; Alice Ammerman, Dr. P.H., University of North Carolina; Laura K. Brennan, PhD, MPH, Transtria
Total Running Time: 01:57:42
Category: BSSR Lecture Series
Chaired by Patricia L. Mabry, Ph.D., Office of Behavioral and Social Sciences Research, NIH. Speakers: Hazhir Rahmandad, Ph.D, Virginia Tech; Peter Hovmand, Ph.D., Washington University; Alice Ammerman, Dr. P.H., University of North Carolina; Laura K. Brennan, PhD, MPH, Transtria
Total Running Time: 01:57:42
Category: BSSR Lecture Series
To view the videocast, please go to: http://videocast.nih.gov/launch.asp?16756
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