Editors: A. Vidal-Puig & R.Unger
“It was sometime in March 2009 when our colleague Fritz Spener first proposed a special issue of BBA Molecular and Cell Biology of Lipids focused on the concept of lipotoxicity and its relevance as an integrative pathogenic mechanism of the metabolic syndrome. Although we might have hesitated a little initially, this did not last long as we realised that: a) ours would be a unique, high quality publication addressing the topic in depth and globally; b) this is an important area of research with enormous implications for metabolic disease and, in our opinion, its relevance is underestimated and relatively unknown among both the biomedical community and general public; and c) the great opportunities offered by new technologies and experimental models to understand the role of lipotoxicity in common metabolic diseases makes this a very timely issue. And also, of course, we expected strong support from the “lipotoxic community”. Certainly we have not been disappointed. In fact our colleagues have provided enormous support and their generosity has made this issue viable. Our only regret is that we have not been able to involve as many of the key experts as we wanted due to space constrains and the time scale of the project, and we hope this will not be the cause of any lost friendships!”
Here is the special issue: Special issue on lipotoxicity.
Here is the special issue: Special issue on lipotoxicity.
This issue isn’t new. I have got the similar hypothesis after I attended a lecture by J. Denis McGarry in 2001 (In memory of Dr. John Denis McGarry. His article "What if Minkowski Had Been Ageusic?" is on the wall of my office all the time). I put this special issue on my blog to remind me keeping work on this hypothesis.
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