Key Question 1: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative effectiveness of these treatment options (see list of comparisons) for the intermediate outcomes of glycemic control (in terms of HbA1c), weight, or lipids?
Key Question 2: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative effectiveness of the treatment options (see list of comparisons) in terms of the following long-term clinical outcomes?
Key Question 2: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative effectiveness of the treatment options (see list of comparisons) in terms of the following long-term clinical outcomes?
Key Question 3: In adults age 18 or older with type 2 diabetes mellitus, what is the comparative safety of the treatment options (see list of comparisons) in terms of the following adverse events and side effects?
Key Question 4: Do the safety and effectiveness of these treatment options (see list of comparisons) differ across subgroups of adults with type 2 diabetes, in particular for adults age 65 or older, in terms of mortality, hypoglycemia, cardiovascular, and cerebrovascular outcomes?
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