Showing posts with label Articles. Show all posts
Showing posts with label Articles. Show all posts

Friday, August 11, 2017

continuing professional education

Continuing Professional Education & Glossary by JECH


2008
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2005
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2003

Monday, July 10, 2017

The Celiac Surge

Article: The Celiac Surge
by Catherine Offord (TheScientist)
A rapid increase in the global incidence of the condition has researchers scrambling to understand the causes of the trend, and cope with the consequences. (Full Text)
Inforgraphic: Immune Irritation in the Gut

Tuesday, September 11, 2012

Geriatric Obesity - a Special Issue of International Journal of Obesity


International Journal of Obesity just released a special issue on geriatiric obesity. It concluded that more research is needed to clarify the definition, to evaluate the tiem of treatment, and  strategies treatment of obesity in older adults.
Scoping review report: obesity in older adults

Obesity in the elderly: an emerging health issue

Wednesday, March 23, 2011

Journal: Significance

Significance is a quarterly magazine for anyone interested in statistics and the analysis and interpretation of data. Its aim is to communicate and demonstrate in an entertaining, thought-provoking and non-technical way the practical use of statistics in all walks of life and to show informatively and authoritatively how statistics benefit society.

Sunday, January 02, 2011

Obesity and Diabetes Articles

Obesity and Diabetes Articles

Tuesday, February 26, 2008

Use of Alternative Thresholds Defining Insulin Resistance to Predict Incident Type 2 Diabetes Mellitus and Cardiovascular Disease -- Rutter et al. 117 (8): 1003 -- Circulation

Use of Alternative Thresholds Defining Insulin Resistance to Predict Incident Type 2 Diabetes Mellitus and Cardiovascular Disease
Source: Circulation

Background- The performance characteristics of surrogate insulin resistance (IR) measures, commonly defined as the top 25% of the measure's distribution, used to predict incident type 2 diabetes mellitus (DM) and cardiovascular disease (CVD) have not been critically assessed in community samples.  Methods and Results- Baseline IR was assessed among 2720 Framingham Offspring Study subjects by use of fasting insulin, the homeostasis model assessment of IR (HOMA-IR), and the reciprocal of the Gutt insulin sensitivity index, with 7- to 11-year follow-up for incident DM (130 cases) or CVD (235). Area under the receiver operating characteristic curve, sensitivity, specificity, and positive likelihood ratio were estimated at 12 diagnostic thresholds (quantiles) of IR measures. Positive likelihood ratios for DM or CVD increased in relation to IR quantiles; risk gradients were greater for DM than for CVD, with no 9th to 10th quantile (76th centile) threshold effects. IR had better discrimination for incident DM than for CVD (HOMA-IR area under the receiver operating characteristic curve: DM 0.80 versus CVD 0.63). The HOMA-IR 76th centile threshold was associated with these test-performance values: sensitivity (DM 68%, CVD 40%), specificity (DM 77%, CVD 76%), and positive likelihood ratio (DM 3.0, CVD 1.7). The HOMA-IR threshold that yielded >90% sensitivity was the 6th quantile for DM prediction and the 3rd quantile for CVD. Compared with the 76th centile threshold, these alternative thresholds yielded lower specificity (DM 43%, CVD 17%) and positive likelihood ratios (DM 1.6, CVD 1.1).  Conclusions- Surrogate IR measures have modest performance at the 76th centile, with no threshold effects. Different centile thresholds might be selected to optimize sensitivity versus specificity for DM versus CVD prediction if  surrogate IR measures are used for risk prediction.